CURRENT RESEARCH STUDIES

This study aims to examine the acceptability and effectiveness of FlyBand to: A) Improve adherence with protective footwear, especially in the at-home environment; B) Improve restoration of motor function through recovery of gait and balance; C) Increase physical activity after post-treatment isolation.

This study would like to identify risk factors related to amputations among self-reported Hispanic and Native American patients with diabetic foot ulcers.

Study would like to develop a peer support program that helps improve ulcer care in patients with diabetic foot ulcer (DFU).

Study will compare patient-centered outcomes of one-stage and two-stage brachial-basilic arteriovenous fistulas (BBAVF) for hemodialysis access.

Extension study of participants who completed EP0162 to assess long-term safety and efficacy following multiple administrations of Staccato alprazolam in study participants with stereotypical episodes of prolonged seizures in an outpatient setting. Study will enroll patients with history of seizures and caregivers of epilepsy patients taking part in the study and able to recognize and observe the study participant’s seizure

This double-blind, multicenter, phase 3 trial is being conducted to assess the effect of investigational product XEN1101 vs. placebo on reducing focal seizure frequency on adults diagnosed with focal epilepsy

Pilot testing of a Novel Gait Tracking System for those with Lower-Limb Amputation (Sensoria Walk): A Pilot Study

Phase 3 study that would like to assess the safety and efficacy of 400 Units [U] of NT 201 in the treatment of adult lower limb spasticity involving the ankle plantar flexors.

This pilot project involves the creation of a database on non-traumatic spinal cord injuries (ntSCI), including transverse myelitis, infections, neoplasms, arthritis, degenerative spine problems, and other nontraumatic health conditions.

The purpose of this investigation is to evaluate the effectiveness of the Rancho Works Café and Gift Shop Program in increasing the return-to-work rate in former Rancho patients with paralysis and are participating in a return to work program. Our goal is to serve as a model for competitive integrated employment - where our graduates are working within an integrated setting earning at least minimum wage or higher and at a rate comparable to non-disabled workers performing the same tasks.

Pilot project that utilizes transcutaneous spinal cord stimulation (TSCS) technology in conjunction with various rehabilitation activities and biomechanical assessments to evaluate TSCS' ability to improve lower extremity function in individuals with SCI versus standard clinical practice. Study participation can last up to 2 years and participants will come to Rancho 2-3x a week to perform different activities. Evaluations will occur every 3 months.

The purpose of this project is to collect and document census and health related information from individuals at the time of sustaining an SCI (Form I) and then at regular follow-up points (Form II) throughout their entire life. Data are collected and stored locally to allow for subsequent analysis of questions related to the prevalence, causes, and treatment of traumatic SCI.

This pilot study leverages low-cost technologies such as smartphone cameras and wearable sensors to develop and evaluate new assessment tools for wheelchair athletes and their coaches.

Multi-center study that will (1) validate a questionnaire-based clinical decision-making tool (called MENTOR) for bowel dysfunction in the acute/subacute population with traumatic Spinal Cord Injury and (2) use the tool from discharge through first year post-injury to describe the progression of bowel dysfunction and if the tool can prompt changes in bowel management when indicated.

This study will conduct a randomized clinical trial to fully evaluate a program for community-based, non-pharmacologic pain management for those with chronic pain after SCI.

Study would like to document and investigate factors that promote successful aging across a wide age range of individuals living with SCI and develop models for examining various factors with long-term changes in quality of life.

This study would like to better understand government benefits and other types of financial assistance used by people after a spinal cord injury to help with daily living expenses as well as identify areas of unmet financial needs and the experience of financial strain after SCI.

The goal of this study is to test a new real-time sensor and feedback system aimed at modifying behavior to improve pressure injury prevention efforts.

Recruited individuals living with spinal cord injury are administered a one-time anonymous survey during the Spinal Injury games to gain a better understanding of the interests and barriers associated with participating in Wheelchair Sport and Recreation (WCSR).

In partnership with the University of Washington (UW), our goal is the trial of the Continuous Positive Airway Pressure (CPAP) support intervention, compared to standard support for CPAP use, among Inpatient Rehabilitation (IPR) patients with stroke and Obstructive Sleep apnea (OSA) to determine its effect on CPAP use.

Study would like to assess an investigational device, named BQ 3.0, that produces and delivers non-invasive and extremely low frequencies to stimulate neural networks to reduce disability and promote neurorecovery for those who have suffered an ischemic stroke. The BQ 3.0 is a wearable device that comes with an application and delivers electromagnetic stimulation to measure the relationship between adherence of the device and its outcomes.

Study will test whether treatment of obstructive sleep apnea (OSA) with Automatically-adjusting continuous positive airway pressure (aCPAP) after recent stroke or high-risk TIA prevents recurrent stroke, acute coronary syndrome, or death.

This study is about a brain-controlled medical device, called a brain-machine interface or BMI, that intends to provide people with spinal cord injury some ability to control an external device such as a computer cursor or robotic limb by using their thoughts along with sensory feedback. The device is implanted at USC then the potential participants are transferred to the Rancho Los Amigos acute care unit for further recovery.

The purpose of this project is to create a database that will organize detailed information about people living with traumatic brain injury (TBI) at Rancho. The database will include personal (such as name, age, diagnosis), medical (such as laboratory and imaging results, hospitalizations, rehabilitation) and information obtained from various questionnaires and interviews (for example, problems experienced by TBI patients and quality of life).

This is a Phase 1/2 study that examines the safety and efficacy of varying doses of a novel chimeric recombinant botulinum toxin (IPN10200) vs. Dysport or placebo in treating adult upper limb (AUL) spasticity in stroke or TBI patients.